AICAR 50mg activates AMP-activated protein kinase (AMPK)

Product introduction：

AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a synthetic compound known for its role in metabolic research. It is a key activator of the AMP-activated protein kinase (AMPK) pathway, which is involved in cellular energy regulation.

Here’s a detailed overview of AICAR, including its effects, administration, and potential considerations:

Overview of AICAR

Mechanism of Action:

1. AMPK Activation: AICAR activates AMP-activated protein kinase (AMPK), a crucial regulator of cellular energy metabolism. AMPK activation leads to increased glucose uptake, enhanced fatty acid oxidation, and improved overall energy balance.
2. Metabolic Effects: By activating AMPK, AICAR can potentially enhance metabolic processes and mimic the effects of exercise on metabolism.

Potential Applications:

1. Metabolic Disorders: AICAR has been studied for its potential to treat metabolic disorders such as type 2 diabetes and obesity by improving insulin sensitivity and glucose metabolism.
2. Athletic Performance: Due to its effects on metabolism, AICAR has attracted interest in the context of athletic performance and endurance. However, its use in competitive sports is banned by the World Anti-Doping Agency (WADA).

How to Use AICAR?

Dosage and Administration:

1. Typical Dosage: In research settings, dosages of AICAR may vary, but 50 mg is a common dosage used in studies. The exact dosage and frequency depend on the research protocol or treatment plan.
2. Administration Route: AICAR is typically administered via subcutaneous injection, which involves injecting the compound into the fatty tissue just beneath the skin. This method allows for gradual absorption into the bloodstream.
3. Preparation: AICAR often comes in a lyophilized (freeze-dried) powder form that needs to be reconstituted with a sterile diluent (e.g., saline) before injection.

Injection Technique:

1. Reconstitution: Reconstitute the powder with a suitable diluent according to the manufacturer’s or study protocol’s instructions.
2. Injection Site: Common sites include the abdomen or the upper thigh. Rotate injection sites to reduce the risk of irritation.
3. Procedure: Clean the injection site with an alcohol swab. Use a sterile syringe and needle to draw the appropriate dose of AICAR. Insert the needle at a 45- to 90-degree angle into the subcutaneous tissue and inject the solution slowly.

Frequency:

1. Protocol-Based: The frequency of injections depends on the research protocol. It may be administered daily, weekly, or according to specific study guidelines.

Storage:

1. Temperature: Store AICAR in its lyophilized form at refrigerated temperatures (2°C to 8°C). After reconstitution, it should be used promptly or stored according to specific instructions.

Potential Effects and Benefits

Metabolic Benefits:

1. Improved Glucose Metabolism: AICAR has been shown to enhance glucose uptake and improve insulin sensitivity.
2. Fat Oxidation: It may increase fatty acid oxidation, potentially aiding in weight management and fat loss.

Exercise Mimicking:

1. Endurance: AICAR can mimic some effects of physical exercise by activating AMPK, which could theoretically improve endurance and physical performance.

Potential Side Effects and Considerations

Injection Site Reactions:

1. Local Irritation: Possible side effects include redness, swelling, or pain at the injection site.

Systemic Effects:

1. Nausea and Fatigue: Some users might experience systemic effects such as nausea or fatigue.
2. Long-Term Safety: The long-term safety and effects of AICAR in humans are not fully established. More research is needed to understand its safety profile thoroughly.

Regulatory and Ethical Issues:

1. Anti-Doping: AICAR is prohibited in competitive sports due to its potential to enhance performance. Use in athletics could result in disqualification or other penalties.

Medical Supervision:

1. Consultation: Always consult with a healthcare professional before using AICAR, especially for its potential therapeutic applications.

Summary

AICAR is a compound with potential metabolic benefits, including improved glucose metabolism and fat oxidation, and may mimic some effects of exercise. It is administered via subcutaneous injection, with dosages typically around 50 mg in research settings. Potential side effects include local injection reactions and systemic effects like nausea. AICAR is banned in competitive sports and should be used under medical supervision if considered for therapeutic purposes. Further research is needed to fully establish its safety and efficacy.

Effects of AICAR

Potential Therapeutic Benefits:

1. Type 2 Diabetes: AICAR’s ability to improve insulin sensitivity and glucose metabolism suggests potential benefits for managing type 2 diabetes and other metabolic disorders.
2. Obesity and Weight Management: By enhancing fat oxidation, AICAR could contribute to weight management and fat loss.

Cellular and Molecular Effects:

1. Gene Expression: AICAR influences the expression of genes related to metabolism, such as those involved in lipid and glucose metabolism, thereby contributing to its metabolic effects.
2. Energy Balance: It helps regulate energy balance by affecting various metabolic pathways and enhancing cellular energy production.

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